Expression of SERCA isoform with faster Ca transport properties improves postischemic cardiac function and Ca handling and decreases myocardial infarction
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چکیده
M. A. Hassan Talukder, Anuradha Kalyanasundaram, Xue Zhao, Li Zuo, Poornima Bhupathy, Gopal J. Babu, Arturo J. Cardounel, Muthu Periasamy, and Jay L. Zweier Davis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, and Department of Cell Biology and Physiology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio; and Department of Cardiology, Shanghai Changzheng Hospital, Shanghai, China
منابع مشابه
Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.
Myocardial ischemia-reperfusion (I/R) injury is associated with contractile dysfunction, arrhythmias, and myocyte death. Intracellular Ca(2+) overload with reduced activity of sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) is a critical mechanism of this injury. Although upregulation of SERCA function is well documented to improve postischemic cardiac function, there are conflicting reports...
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Ectopic expression of the sarcoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) 1a pump in the mouse heart results in a 2.5-fold increase in total SERCA pump level. SERCA1a hearts show increased rates of contraction/relaxation and enhanced Ca(2+) transients; however, the cellular mechanisms underlying altered Ca(2+) handling in SERCA1a transgenic (TG) hearts are unknown. In this study, using confoc...
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In this study, we investigated whether the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca transport pump (SERCA1a) can functionally substitute the cardiac SERCA2a isoform and how its overexpression affects cardiac contractility. For this purpose, we generated transgenic (TG) mice that specifically overexpress SERCA1a in the heart, using the cardiac-specific a-myosin heavy chain pro...
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تاریخ انتشار 2007